Ketamine-Propofol Sedation in Circumcision
Abstract
Background
and
objective:
To
compare
the
therapeutic
effects
of
ketamine
alone
or
ketamine
plus
propofol
on
analgesia,
sedation,
recovery
time,
side
effects
in
premedicated
children
with
midazolam---ketamine---atropin
who
are
prepared
circumcision
operation.
Methods:
60
American
Society
of
Anaesthesiologists
physical
status
I---II
children,
aged
between
3
and
9
years,
undergoing
circumcision
operations
under
sedation
were
recruited
according
to
a
randomize
and
double-blind
institutional
review
board-approved
protocol.
Patients
were
randomized
into
two
groups
via
sealed
envelope
assignment.
Both
groups
were
administered
a
mixture
of
midazolam
0.05
mg/kg
+
ketamine
3
mg/kg
+
atropine
0.02
mg/kg
intramuscularly
in
the
presence
of
parents
in
the
pre-operative
holding
area.
Patients
were
induced
with
propofol---ketamine
in
Group
I
or
ketamine
alone
in
Group
II.
Results:
In
the
between-group
comparisons,
age,
weight,
initial
systolic
blood
pressure,
a
dif-
ference
in
terms
of
the
initial
pulse
rate
was
observed
(
p
>
0.050).
Initial
diastolic
blood
pressure
and
subsequent
serial
measurements
of
5,
10,
15,
20th
min,
systolic
blood
pressure,
diastolic
blood
pressure
and
pulse
rate
in
ketamine
group
were
significantly
higher
(
p
<
0.050).
Conclusion:
Propofol-ketamine
(Ketofol)
provided
better
sedation
quality
and
hemodynamy
than
ketamine
alone
in
pediatric
circumcision
operations.
We
did
not
observe
significant
complications
during
sedation
in
these
two
groups.
Therefore,
ketofol
appears
to
be
an
effective
and
safe
sedation
method
for
circumcision
operation.